Transforming the World with AI and Advanced Computing | SandboxAQ

CNBC

DoW Partners with SandboxAQ for AI & Post-Quantum Cryptography Defense

Bahrain's sovereign fund, SandboxAQ sign deal to speed up drug discovery with AI

Introducing AQCat25-EV2 Models

The first AI model for heterogeneous catalysis achieving quantum-level accuracy for all industrially relevant atom types

SandboxAQ and the OpenFold Consortium Launch OpenFold3

Fully Open-Source Frontier AI for Structure-Aware Drug Discovery.

Announcing SAIR

The Largest Publicly Available Binding Affinity Dataset with Cofolded 3D Structures

Where LQMs Are Making an Impact Today

SandboxAQ Redefines Cybersecurity with Unified Cryptography Management

Drug Discovery

Accelerating the design of new therapeutics with quantitative AI grounded in physics and chemistry.

SandboxAQ Redefines Cybersecurity with Unified Cryptography Management

New Chemicals & Materials

Predicting properties at the atomic level to unlock breakthrough materials.

SandboxAQ Redefines Cybersecurity with Unified Cryptography Management

Cybersecurity

Mapping vulnerabilities and optimizing resilience across digital infrastructure.

SandboxAQ Redefines Cybersecurity with Unified Cryptography Management

Navigation

Enhancing autonomy and precision in GPS-denied and complex environments.

SandboxAQ Redefines Cybersecurity with Unified Cryptography Management

Medical Diagnostics

Improving diagnosis and treatment planning through advanced AI-driven cardiac signal analysis.

Why Visionaries Are Partnering with SandboxAQ

"I invested in SandboxAQ because of their industry-leading approach to quantitative AI. While LLMs are very helpful tools for consumers, it is quantitative AI that will define work in large sectors of the economy including biopharma, chemicals and financial services. I am impressed by the technical depth of Jack and his team and am excited to support their work. SandboxAQ has emerged as a leader in novel applications of AI that solve the most pressing challenges in the world and their technical success is impressive."

– Yann LeCun, leading AI scientist, one of three Turing Award winners for deep learning

"We are proud investors in SandboxAQ. We believe deeply in Jack and his team, and are committed to their vision to advance technology and transform industries through their leadership in the next wave of AI and its connection with quantum technologies. We support SandboxAQ’s portfolio approach to developing novel products in cybersecurity, navigation, and AI simulation, and are seeing their successes reflected in customer engagement. Jack and the team combine vision and execution and we are excited to grow with him and the company."

– USIT Investment Fund

"I am very excited to see the continued success of SandboxAQ. As part of the spinout team and now as a senior advisor, it is very gratifying to see all the hard work translate into real impact in the world. SandboxAQ’s combination of AI and quantum tools is changing the game in sectors such as biopharma, materials and cyber. Jack and the team are leading the company to new achievements and I look forward to continued involvement with the company as it grows further."

– Jen Sovada, Senior Advisor, SandboxAQ

“We’re proud to be backing SandboxAQ and its impressive accomplishments. Jack and his team have surpassed the expectations they set when we invested and we look forward to their continued success. Jack is a world-class leader who uniquely combines technical and business skills to execute on this vision with his team. SandboxAQ is the pacesetter in quantitative AI which has impact in multiple large sectors of the economy.”

– Jim Breyer, CEO, Breyer Capital

Trusted by Leading Global Enterprises

Why LQMs, Why Now

‍

Rooted in Science → Trained on the laws of nature
Engineered for Impact → From molecular modeling to cyber defense
Real-World Solutions → Clear outputs, reduced uncertainty
Proven & Scalable → Already deployed in high-stakes domains

Agentic AI Chemist – A New Era of Autonomous Discovery

Smarter Autonomy
Autonomously explores millions of potential chemical pathways, far beyond what a human chemist could evaluate, enabling the discovery of novel molecules and the optimization of compounds for clinical and scale-up success.
‍
Transformation at Scale
‍Combines and orchestrates multiple LQMs to transform the scale of the research and development process.

Our Investors

Our Partners and Collaborators

Explore how LQMs could transform your enterprise!

Subscribe to LQM Insights

We’re not just building smarter models. We’re building AI that understands the physical world. This is Quantitative AI.

Photo by SrA Alexander Merchak

SandboxAQ’s SAIR dataset turns 5.2 M protein‑ligand structures into ground‑truth fuel for AI

Photo by SrA Alexander Merchak

Alphabet's SandboxAQ teams up with Florida biotech to develop mRNA cancer vaccine

Photo by SrA Alexander Merchak

The Secret to Better Airplane Navigation Could Be Inside the Earth’s Crust

Photo by SrA Alexander Merchak

Targeting The Heart With AI

Photo by SrA Alexander Merchak

Nvidia-backed AI startup SandboxAQ creates new data to speed up drug discovery

Photo by SrA Alexander Merchak

SandboxAQ, Nvidia expand quantum AI collaboration

Photo by SrA Alexander Merchak

This $5.6 billion Google AI Spinoff Invents New Products from Numerical Data

Photo by SrA Alexander Merchak

SandboxAQ Helps Unlock the Next Generation of AI-Driven Chemistry with NVIDIA Technology

Photo by SrA Alexander Merchak

KU Leuven and SandboxAQ Partner to Accelerate the Search for Parkinson’s Treatments with AI

Photo by SrA Alexander Merchak

U.S. Army Uses AI to Improve Battery Life, Performance

Photo by SrA Alexander Merchak

Aramco and SandboxAQ Sign AI Agreement

Podcast

Large Quantitative Models Are Revolutionizing AI and Industries

Podcast

AI explained - LQMs | AI Anchored in the Physical World

Podcast

CNBC: Partnering on Large Quantitative Models

Podcast

How AI & Quantum Simulation are Revolutionizing Medical Breakthroughs

Podcast

AI, Quantum, and the Future of Financial Markets

Podcast

Stop Guessing, Start Predicting: LQMs and the New Era of Scientific Discovery

Podcast

Building Better Batteries with LQMs

Podcast

Quantitative AI: Transforming Industries with Large Quantitative Models

Podcast

SandboxAQ Supports the Open Molecular Software Foundation to Advance Simulation in Life Sciences and Materials Science

Podcast

How the AI and Quantum Revolution Will Transform Drug Discovery and Medical Diagnostics

Photo by SrA Alexander Merchak

Guided Multi-Objective Generative AI to Enhance Structure-based Drug Design

Photo by SrA Alexander Merchak

Accelerated Organic Crystal Structure Prediction with Genetic Algorithms and Machine Learning

Podcast

Massively Parallel Quantum Chemistry: PFAS on Over 1 Million Cloud vCPUs

Podcast

Machine Learning Guided AQFEP: A Fast & Efficient Absolute Free Energy Perturbation Solution for Virtual Screening

Podcast

Orbital Optimization of Large Active Spaces via AI-Accelerators

Podcast

Parallel Implementation of the Density Matrix Renormalization Group Method Achieving a Quarter petaFLOPS Performance on a Single DGX-H100 GPU Node